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Safety, Pharmacokinetics, and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator Dazucorilant in Healthy Volunteers
Donaldson et al. • 2023 • ENCALS Meeting 2023
DAZALS: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Dazucorilant in Patients with Amyotrophic Lateral Sclerosis
Mann et al • 2022 • European Network to Cure ALS (ENCALS)
Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).
Webster et al. • 2017 • Br J Pharmacol. 2017;174(5):396-408.
New selective glucocorticoid receptor modulators reverse amyloid-β peptide-induced hippocampus toxicity.
Pineau et al. • 2016 • Neurobiol Aging. 2016;45:109-122.
The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice.
Meyer et al. • 2014 • J Steroid Biochem Mol Biol. 2014 Sep;143:40-8.
Age- and sex-dependent effects of early life stress on hippocampal neurogenesis.
Loi et al. • 2014 • Front Endocrinol (Lausanne). 2014;5:13.
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Baglietto-Vargas et al. • 2013 • Biol Psychiatry. 2013;74(5):357-66.
A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation.
Hu et al. • 2012 • PLoS One. 2012;7(9):e46224.
Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: towards a rescue strategy.
Claessens et al. • 2012 • Brain Res. 2012;1482:1-12.