High Medication and Cardiovascular Disease Burden in Individuals With Difficult-to-Control Type 2 Diabetes: Clinical Characteristics From the CATALYST Study

Summary

At >1,000 participants, CATALYST Part 1 was the largest prospective study to investigate endogenous hypercortisolism in individuals with difficult-to-control type 2 diabetes, finding a prevalence of 23.8%
CATALYST Part 1 participants reported using a median of 10 medications, with 43% taking ≥4 glucose-lowering medications, 27% taking ≥3 antihypertensives, and 30% using psychiatric or analgesic medications
CATALYST participants had persistently elevated hemoglobin A1c despite the use of multiple glucose-lowering medications
Participants in CATALYST had a high cardiovascular disease burden, with a significantly higher prevalence of overall cardiovascular disease, coronary artery disease, atrial fibrillation, and heart failure in those with vs without hypercortisolism