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Safety, Pharmacokinetics, and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator Dazucorilant in Healthy Volunteers

October 6, 2023

Donaldson et al. • 2023 • NEALS 22nd Annual Meeting

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https://corcept.com/wp-content/uploads/COR-logo.svg 0 0 jeremiah@devisedesigns.com https://corcept.com/wp-content/uploads/COR-logo.svg jeremiah@devisedesigns.com2023-10-06 00:00:002023-10-06 00:00:00Safety, Pharmacokinetics, and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator Dazucorilant in Healthy Volunteers

https://corcept.com/wp-content/uploads/2023/01/ENCALS2023-1.pdf

July 13, 2023

Donaldson et al. • 2023 • ENCALS Meeting 2023

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DAZALS: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Dazucorilant in Patients with Amyotrophic Lateral Sclerosis

February 3, 2023

Mann et al • 2022 • European Network to Cure ALS (ENCALS)

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Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).

November 15, 2017

Webster et al. • 2017 • Br J Pharmacol. 2017;174(5):396-408.

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https://corcept.com/wp-content/uploads/COR-logo.svg 0 0 jeremiah@devisedesigns.com https://corcept.com/wp-content/uploads/COR-logo.svg jeremiah@devisedesigns.com2017-11-15 00:00:002024-03-14 21:45:03Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).

New selective glucocorticoid receptor modulators reverse amyloid-β peptide-induced hippocampus toxicity.

November 15, 2016

Pineau et al. • 2016 • Neurobiol Aging. 2016;45:109-122.

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https://corcept.com/wp-content/uploads/COR-logo.svg 0 0 jeremiah@devisedesigns.com https://corcept.com/wp-content/uploads/COR-logo.svg jeremiah@devisedesigns.com2016-11-15 00:00:002024-03-14 21:45:45New selective glucocorticoid receptor modulators reverse amyloid-β peptide-induced hippocampus toxicity.

The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice.

November 5, 2014

Meyer et al. • 2014 • J Steroid Biochem Mol Biol. 2014 Sep;143:40-8.

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https://corcept.com/wp-content/uploads/COR-logo.svg 0 0 jeremiah@devisedesigns.com https://corcept.com/wp-content/uploads/COR-logo.svg jeremiah@devisedesigns.com2014-11-05 00:00:002024-03-14 21:54:57The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice.

Age- and sex-dependent effects of early life stress on hippocampal neurogenesis.

May 15, 2014

Loi et al. • 2014 • Front Endocrinol (Lausanne). 2014;5:13.

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https://corcept.com/wp-content/uploads/COR-logo.svg 0 0 jeremiah@devisedesigns.com https://corcept.com/wp-content/uploads/COR-logo.svg jeremiah@devisedesigns.com2014-05-15 00:00:002024-03-15 21:54:48Age- and sex-dependent effects of early life stress on hippocampal neurogenesis.

Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.

November 15, 2013

Baglietto-Vargas et al. • 2013 • Biol Psychiatry. 2013;74(5):357-66.

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https://corcept.com/wp-content/uploads/COR-logo.svg 0 0 jeremiah@devisedesigns.com https://corcept.com/wp-content/uploads/COR-logo.svg jeremiah@devisedesigns.com2013-11-15 00:00:002024-03-15 21:52:28Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.

A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation.

August 15, 2012

Hu et al. • 2012 • PLoS One. 2012;7(9):e46224.

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https://corcept.com/wp-content/uploads/COR-logo.svg 0 0 jeremiah@devisedesigns.com https://corcept.com/wp-content/uploads/COR-logo.svg jeremiah@devisedesigns.com2012-08-15 00:00:002024-03-15 21:53:56A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation.

Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: towards a rescue strategy.

July 15, 2012

Claessens et al. • 2012 • Brain Res. 2012;1482:1-12.

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https://corcept.com/wp-content/uploads/COR-logo.svg 0 0 jeremiah@devisedesigns.com https://corcept.com/wp-content/uploads/COR-logo.svg jeremiah@devisedesigns.com2012-07-15 00:00:002024-03-15 21:54:22Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: towards a rescue strategy.
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