A mixed glucocorticoid/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats.
Nguyen et al. • 2017 • Physiol Behav. 2017;178:82-92.
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The selective glucocorticoid receptor antagonist CORT 108297 decreases neuroendocrine stress responses and immobility in the forced swim test.
Solomon et al. • 2014 • Horm Behav. 2014;65(4):363-71.
Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.
Zalachoras et al. • 2013 • Proc Natl Acad Sci U S A. 2013;110(19):7910-7915.
Antiglucocorticoid therapy for older adults with anxiety and co-occurring cognitive dysfunction: results from a pilot study with mifepristone.
Lenze et al. • 2014 • Int J Geriatr Psychiatry. 2014;29(9):962-9.
Rapid reversal of acute psychosis in the Cushing syndrome with the cortisol-receptor antagonist mifepristone (RU 486).
van der Lely et al. • 1991 • Ann Intern Med. 1991;114(2):143-4.
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile.
Hunt et al. • 2015 • Bioorg Med Chem Lett. 2015;25(24):5720-5.
Comparison of direct action of thiazolidinediones and glucocorticoids on renal podocytes: protection from injury and molecular effects.
Agrawal et al. • 2011 • Mol Pharmacol. 2011;80(3):389-99.
Administration of a selective glucocorticoid antagonist attenuates electroconvulsive shock-induced retrograde amnesia.
Andrade et al. • 2012 • J Neural Transm (Vienna). 2012;119(3):337-44.
Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).
Webster et al. • 2017 • Br J Pharmacol. 2017;174(5):396-408.
High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer
Veneris et al • 2017 • Gynecol Oncol.